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Triple-mutants of covid detected in India; What is triple mutant virus?

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COVID-19 virus outbreaks are increasing rapidly in India, the double mutants of corona strain B.1.167 are believed to be responsible for the second wave of COVID-19 infection.

Now media reports said that third mutants have been identified in B.1.167 in the country. It is being said that the third mutant has knocked out due to the lack of genome sequencing of double mutants.

The double mutants E484Q and L425R were located in the spike proteins of the virus, which bind it to receptor cells in the body. To prevent these destructive forms of corona, genes had to be monitored at large levels, but this did not happen.

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The practice of already slow-moving genome sequencing slowed down between November and January due to lack of funding, absence of clear instructions.

As a result, now, a third mutant has been identified in B.1.167 and experts are hoping that concrete steps should be taken without delay to prevent its spread. 

According to the report, the first two variants of the triple mutant variant have been found in Maharashtra, Delhi, West Bengal and Chhattisgarh. 

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Cases are increasing rapidly in all these states.The third variant of the triple mutant variant has also been found in 17 samples from Maharashtra, Delhi and West Bengal.

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A source said, “West Bengal is becoming the center of such mutations. The new triple mutants may make the virus more capable of escaping from the human immune system.”

According to the report of Indian Express, several sources have told The Indian Express that last week, the Ministry of Health had informed about the possibility of developing another mutant ‘triple-mutant’ from this double mutant and three different varieties. Has been detected. 

Two of the triple-mutant varieties have new mutations in spike proteins and have been found in samples collected from Maharashtra, Delhi, West Bengal and Chhattisgarh. The third variant of strain involves mutations outside the spike protein. But it is still considered important and has been seen again in 17 specimens in Maharashtra, Delhi and West Bengal.

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According to one source, West Bengal is becoming the center of attraction for such mutations. New triple mutants may make the virus even more capable of developing the human immune response. This requires a lot of sequencing of many samples.

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Sources also said that we do not know which version is contributing to the second wave. We have no way. It can be B.1.617 or B.1.1.7 or both. This is why genomic sequencing is so important.

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