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How marriage in close relations causing genetic diseases in children

How marriage in close relations causing genetic diseases in children

Ground Report | New Delhi: Marriage in close relations; In many countries marrying with close relations is a tradition. Muslim community where marry with his close relation like first relation and also second relation. In North Africa, the Middle East and West Asia are  Consanguineous marriages. Where highly Consanguineous marriages are seen in Pakistan, Turkey, North Africa.

While in Kashmir people marry their cousin’s they also faced some genetic problems in their babies. The frequency of genetic disorders among such children is around twice that in children of non-related parents.

Marriage in close relations

A scientific study published today in The Journal of Genetic Counseling ensures that first cousins ​​can have children with each other without their children having great risks of suffering from genetic malformations or other types of congenital diseases, according to the New York Times. Contrary to popular belief, there are no biological reasons to discourage first cousins ​​from having children. The study’s conclusions are the result of a review of six studies conducted from 1965 to August 2000, analyzing thousands of cases.

Although the risk of having a child with malformations among first cousins ​​is greater than among unrelated parents, the risk is not as great as most people think, according to the study by Dr Arno Motulsky, professor emeritus of medicine and genetics from the University of Washington. The general population risk of having a child with spina bifida or fibrosis problems is 3 or 4%, to this risk, first cousins ​​should add only 1.7 to 2.8%.

In Parental consanguinity has been associated With stillbirths, low birth weight, preterm delivery, Abortion, infant and child mortality, congenital Birth defects, cognitive impairments, Cardiovascular risks, malformations, and several other complex disorders.

People give much preference to the Consanguineous marriage are primarily social. Many sociological studies said that consanguinity marriages could enforce the couples’ stability due to higher compatibility between husband and wife who share the same social relationships after marriage as before marriage, as well as the compatibility between the couple and other family members.

While babies born out of such marriage could have a multiplicity problems. Heart  problems are highly, limb anomalies, and nervous disorders.

Eamonn Sheridan, a researcher at the University of Leeds, is leading a team of researchers who surveyed births at Bradford Central Hospital. The results of the survey showed that there were 13,500 babies born between 2007 and 2011. Of these, 11,396 children’s family data or essential details were already known to researchers. 18% of these children were born as a result of marriages between first cousins ​​or cousins. The couple was mostly from Pakistan.

Three per cent of the total children in the survey, or 386 newborns, were found to have some form of anomaly or health problems. They found defects in the nervous system, respiratory system and digestive system. In addition, these children were found to have urinary and genital diseases and defects such as mismatch in the excess of right and left palate. 

The study also found that Bradford, a city in the United Kingdom, had twice as many cases of the newborn’s disease as the national average. Researchers have ruled out the possibility of these diseases and other genetic defects in newborns, such as alcohol use, smoking and social deprivation.

Impact of double recessive genes

Each ordinary individual has 23 sets of chromosomes. In an aggregate of 46 chromosomes, a youngster gets half of its set from their dad and a big part of the set from their mom. However, a vital point that we want to know here is – that each pair of chromosomes contains a predominant and a latent quality or characteristic. In the event of mono-zygotic(identical) twins, the kin share 100 per cent of their qualities. In a parent-kid case, a kid imparts half of its qualities to their parent. So does the kin. Presently, in the event that we talk about cousins – (explicitly first cousins), they share very nearly 8 of their qualities.

In this way, in a couple of 23 chromosomes, marriage between cousins drives what is going on where their kid will get comparable pair of 8 qualities from their folks. Presently, being of similar quality, there is a higher opportunity that the kid will get both latent qualities from their folks.

Accordingly, when contrasted with out-of-the-family marriage, kids conceived out of cousin relationships are in danger of having an autosomal passive condition. This sort of condition is brought about by having a “twofold portion” of a broken quality.

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